Peptides are one of the most exciting groups of active ingredients in skincare, and they're mainly used for anti-aging. They work gently but effectively to improve your skin's structure, help prevent wrinkles, boost hydration, and support your skin's barrier.
What is a peptide, exactly?
Peptides are short chains of amino acids that occur naturally in your skin. When you apply them topically, they can send signals to your skin — telling it to produce more collagen or elastin, for example. Some peptides soothe; others firm or hydrate.
The most popular peptides and what they do
Anti-aging serums in GrailOne of the original and most well-known peptides. It boosts collagen production, smooths fine lines, and with regular use leaves skin looking visibly firmer.
What to look out for:- Often marketed as "Matrixyl" — but on the INCI list, look for Palmitoyl Pentapeptide-4.
- Works well alongside hyaluronic acid and antioxidants.
- Best in your evening routine, though it isn't photosensitizing.
A peptide combo that calms inflammation and boosts elasticity. Great for mature, sensitive, or easily-irritated skin.
What to look out for:- Also commonly marketed as "Matrixyl 3000."
- A gentler alternative to retinol if your skin is sensitive.
- Results take time — expect to use it consistently for 2–3 months.
Often called "Botox lite." It reduces muscle contractions to soften expression lines, especially on the forehead and around the eyes.
What to look out for:- Its small molecule size lets it absorb well into the skin.
- Gives instant — but temporary — firmness.
- Can be used both morning and evening.
A copper peptide that supports wound healing and has anti-inflammatory and antioxidant properties. It helps skin regenerate and is especially good for post-acne damage.
What to look out for:- Listed on INCI as Copper Tripeptide-1 or GHK-Cu.
- Well-tolerated even on sensitive skin.
- Don't use it at the same time as acids or strong antioxidants (like vitamin C) — they can cancel each other out.
Signal peptides vs. carrier peptides
Anti-wrinkle creams in Grail- Signal peptides: trigger your skin cells to produce more collagen.
- Carrier peptides: help deliver other actives (like copper) into the right layer of skin.
- Some peptide complexes combine several functions in a single formula.
How to choose a product with peptides
Anti-aging creams in Grail- Look for specific peptide names on the INCI list — not just marketing copy.
- Check where it appears on the ingredient list. The higher up, the more there is in the formula.
- Pair them with moisturizers or hyaluronic acid for even better results.
- Avoid stacking peptides with lots of acids or strong exfoliating actives in the same routine.